专利名称：Immunoglobulin adsorbent and adsorption
apparatus
发明人：Yuichi Yamamoto,Tadashi Sameshima申请号：US06/849068申请日：19860407公开号：US04705628A公开日：19871110
摘要：For the treatment of various diseases including autoimmune diseases such asmyathenia gravis, articular rhematism, lupus erythematosus, etc., immunity-relateddiseases such as glumerulonephritis, bronchial asthma, polyneuritis, etc., organ
transplantation such as transplanted kidney rejection, AOB incompatibility bone marrowtransplantation, etc., tumor, hypertension, and hepatic insufficiency, immunoglobulinadsorbents comprising a hydroxyl-containing water- insoluble carrier to which a diaminecompound having the general formula: ##EQU1## wherein n is an integer having a valueof 3 to 9 is attached through a silane coupling agent or a derivative thereof, to whichdiamine a heterocyclic compound is attached through a difunctional reagent, are usefulas they can selectively and efficiently adsorb specific proteins such as immunoglobulinsand immune complexes which are pathogenic substances in the diseases, exhibitminimized non-specific adsorption, and are safe and easy to sterilize.
申请人：TERUMO KABUSHIKI KAISHA
代理机构：Burns, Doane, Swecker & Mathis
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